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A few of the metabolites of oxycodone have also been found to be active as MOR agonists, some of which notably have much higher affinity for (as well as higher efficacy at) the MOR in comparison. Oxymorphone possesses 3- to 5-fold higher affinity for the MOR than does oxycodone, while noroxycodone and noroxymorphone possess one-third of and 3-fold higher affinity for the MOR, respectively, and MOR activation is 5- to 10-fold less with noroxycodone but 2-fold higher with noroxymorphone relative to oxycodone. Noroxycodone, noroxymorphone, and oxymorphone also have longer biological half-lives than oxycodone.
Similarly to most other opioids, oxycodone increases prolactin secretion, but its influence on testosterone levels is unknown. Unlike morphine, oxycodone lacks immunosuppressive activity (measured by natural killer cell activity and interleukin 2 production in vitro); the clinical relevance of this has not been clarified.
As of 2024, the prescribing information for OxyContin still specifies a controversial 12-hour dosing schedule – which experts say promotes addiction – as the only option; it also still states, “there are no well-controlled clinical studies evaluating the safety and efficacy with dosing more frequently than every 12 hours.”
Maincard
Maincard is a sports fantasy card game that rewards players for their sports and esports knowledge. Players earn rewards by accurately predicting the outcomes of real-life sports and esports events using in-game cards. Here you can find traditional sports such as football, basketball, tennis, cricket, etc. as well as esports such as Dota 2, Counter-Strike 2, and League of Legends. The project has its own native token – MCN.
Maincard is an extremely interesting take on the popular Sports Fantasy management niche. Not only does it bring true ownership by using NFTs and crypto but it also offers innovative ways to generate a profit and interact with their fellow fans.
So far, the Fantasy sports industry has been growing based on the efforts of third parties without bringing anything new to the table. Maincard is looking to change this reality by bringing new technologies and making fantasy sports enjoyable again.
Maincard’s marketplace will allow players to trade their maincards in different ways, with upgraded cards being especially in demand. As players truly own their cards due to their NFT nature, this opens the doors for a completely different way of generating profit.
Maincard is a Web3 platform combining fantasy sports with blockchain technology. It allows users to manage virtual sports teams and predict outcomes using NFTs. The platform supports global users and aims to educate them about cryptocurrencies and NFTs.
Smart contract examples
In this Tech Tuesday, Anastasia Lalamentik, Full Stack Engineer at Kaleido, walks through how to write a smart contract and goes over related concepts like gas fees, the Ethereum Virtual Machine (EVM), the block explorer, and the Solidity programming language. The video is a great place to start if you want to learn more about how smart contracts can improve the way we work.
In real estate, smart contracts automate property sales, reducing the need for intermediaries. They ensure secure and transparent transactions, with ownership transfers recorded on the blockchain. This reduces the time and costs associated with property transactions. However, legal recognition of blockchain-based property records varies by jurisdiction. Additionally, the complexity of real estate transactions may require hybrid approaches combining smart contracts with traditional methods.
Smart contracts streamline cross-border payments by automating currency exchange and reducing fees. This eliminates intermediaries, enabling faster and more cost-effective transactions. Companies like Ripple and Stellar use smart contracts to facilitate international money transfers. However, regulatory differences between countries can complicate adoption. Additionally, the technology requires robust infrastructure to handle high transaction volumes.
Co-founder, Hela labs. He received Ph.D. degree from the Nanyang Technological University of Singapore. He leads a team of more than 12 scientists and engineers. He is the author or co-author of 8 peer-reviewed papers in prestigious journals and conferences. His research interest includes Blockchain, FinTech, AI, Real time simulation Computing.
In this Tech Tuesday, Anastasia Lalamentik, Full Stack Engineer at Kaleido, walks through how to write a smart contract and goes over related concepts like gas fees, the Ethereum Virtual Machine (EVM), the block explorer, and the Solidity programming language. The video is a great place to start if you want to learn more about how smart contracts can improve the way we work.
In real estate, smart contracts automate property sales, reducing the need for intermediaries. They ensure secure and transparent transactions, with ownership transfers recorded on the blockchain. This reduces the time and costs associated with property transactions. However, legal recognition of blockchain-based property records varies by jurisdiction. Additionally, the complexity of real estate transactions may require hybrid approaches combining smart contracts with traditional methods.
Upoy coin
UpOnly operates by tapping into a centralized database architecture to collect in-depth data on P2E games. The goal of UpOnly is to become a trusted data source for the P2E gaming market, similar to how CoinMarketCap and CoinGecko are leading data aggregators in the cryptocurrency market.
The native UPO token is at the heart of the UpOnly prediction platform. To bet on the outcome of a play-to-earn game, spectators must hold UPO tokens. Spectators can bet their UPO on the outcome of various play-to-earn games and earn further UPO rewards when they predict the outcome correctly. The decentralized prediction platform will be the first of its kind in the blockchain-based gaming industry. It will be the first infrastructure that allows blockchainbased gaming spectators to monetize their activity and access broader insights and data from the UpOnly platform.
UpOnly collects data from P2E games using a centralized database architecture and data query solutions like The Graph. By providing comprehensive data and insights, UpOnly aims to attract and inform gamers and spectators interested in betting on the outcome of P2E games.
You can securely store your UpOnly in the custodial wallet on the KuCoin exchange without having to worry about managing your private keys. Other ways to store your UPO include using a self-custody wallet (on a web browser, mobile device, or desktop/laptop computer), a hardware wallet, a third-party crypto custody service, or a paper wallet.
Investing in UpOnly(UPO) can seem complicated, but it is much easier when you buy UpOnly(UPO) through a cryptocurrency exchange. Signing up for a cryptocurrency exchange will allow you to buy, sell, and hold UpOnly(UPO) Token — both for fiat money and other cryptocurrencies. Some of the most popular UpOnly(UPO) Token cryptocurrency exchanges are:
